Application | Comment | Organism |
---|---|---|
medicine | prognosis of thyroid carcinoma after surgery is not correlated with the expression GnT-V because the levels of expression is quite low in anaplastic (undifferentiated) carcinomas | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | Homo sapiens | catalyzes the formation of beta-1-6 GlcNAc branches on asparagine-linked oligosaccharides, which is directly linked to tumorigenesis | UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anaplastic thyroid cancer cell | observed in 6/28 cases | Homo sapiens | - |
follicular thyroid cancer cell | oberserved in 10/23 cases | Homo sapiens | - |
additional information | not expressed in normal thyroid tissue | Homo sapiens | - |
papillary thyroid cancer cell | observed in 66/68 cases | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + 6-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | catalyzes the formation of beta-1-6 GlcNAc branches on asparagine-linked oligosaccharides, which is directly linked to tumorigenesis | Homo sapiens | UDP + 6-(2,6-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GnT-V | - |
Homo sapiens |
UDP-N-acetylglucosamine:a-mannoside beta-1,6-N-acetylglucosaminyltransferase | - |
Homo sapiens |